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論文
​論文-Publication-
​２０２３年

Kataba A, Yohannes YB, Nakata H, Yabe J, Toyomaki H, Muzandu K, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M, Nakayama SMM. Association between Chronic Environmental Lead (Pb) Exposure and Cytokines in Males and Females of Reproductive Age from Kabwe, Zambia. Int J Environ Res Public Health 20, 2023.

  1. Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Takiguchi M, Tanabe S, Ishizuka M. Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats. PLoS One 18, 2023.

  2. Kimura M, Shoda A, Murata M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N. Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole. Journal of Veterinary Medical Science Published online 2023.

  3. Kondo M, Ikenaka Y, Nakayama SMM, Kawai YK, Mizukawa H, Mitani Y, Nomyama K, Tanabe S, Ishizuka M. Sulfotransferases (SULTs), enzymatic and genetic variation in Carnivora: Limited sulfation capacity in pinnipeds. Comp Biochem Physiol C Toxicol Pharmacol 263, 109476, 2023.

  4. Motohira K, Yohannes YB, Ikenaka Y, Eguchi A, Nakayama SMM, Wepener V, Smit NJ, VAN VUREN JHJ, Ishizuka M. Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats. Journal of Veterinary Medical Science 85, 236-243, 2023.

  5. Nakamura S, Yamazaki J, Matsumoto N, Inoue-Murayama M, Qi H, Yamanaka M, Nakanishi M, Yanagawa Y, Sashika M, Tsubota T, Ito H, Shimozuru M. Age estimation based on blood DNA methylation levels in brown bears. Mol Ecol Resour Published online March 23, 2023.

  6. Shinya S, Kawai Y, Kondo M, Nakayama SMM, Ishizuka M, Ikenaka Y. Characteristics of cytochrome P450-dependent metabolism against acetamiprid in the musk shrew (Suncus murinus). Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 265, 2023.

  7. Shinya S, Muthusinghe DS, Koizumi N, Yoshimatsu K, Nakayama SMM, Ishizuka M, Ikenaka Y. Effects of Diazinon Exposure on Urinary Shedding of Leptospira interrogans Serogroup Hebdomadis in Mice. Toxics 11, 2023.

  8. Shinya S, Nishibe F, Yohannes YB, Ishizuka M, Nakayama SM, Ikenaka Y. Characteristics of tissue distribution, metabolism, effects on brain catecholamines, and environmental exposure of frogs to neonicotinoid insecticides. Aquatic Toxicology 257, 2023.

  9. Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N. Developmental stage-specific exposure and neurotoxicity evaluation of low-dose clothianidin during neuronal circuit formation. Journal of Veterinary Medical Science Published online 2023.

  10. Shoda A, Nishi M, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N. Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice. Toxicol Lett 373, 33-40, 2023.

  11. Sugawara-Suda M, Morishita K, Ichii O, Namba T, Aoshima K, Kagawa Y, Kim S, Hosoya K, Yokoyama N, Sasaki N, Nakamura K, Yamazaki J, Takiguchi M. Transcriptome and proteome analysis of dogs with precursor targeted immune-mediated anemia treated with splenectomy. PLoS One 18, 2023.

  12. Sugawara-Suda M, Morishita K, Iwanaga Y, Yamazaki J, Kagawa Y, Yokoyama N, Sasaki N, Ohta H, Nakamura K, Takiguchi M. Investigation of the therapeutic effects, predictors, and complications of long-term immunosuppressive therapy in dogs with precursor-targeted immune-mediated anemia. J Vet Med Sci 23-0010, Published online May 29, 2023.. 

  13. Asari Y, Yamazaki J, Thandar O, Suzuki T, Aoshima K, Takeuchi K, Kinoshita R, Kim S, Hosoya K, Ishizaki T, Kagawa Y, Jelinek J, Yokoyama S, Sasaki N, Ohta H, Nakamura K, Takiguchi M. Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours. Vet Med Sci Published online July 22, 2023.

  14. Gerber R, De Necker L, Van Vuren JHJ, Ikenaka Y, Nakayama SMM, Ishizuka M, Wepener V, Smit NJ. A Stable Isotope Analysis Of The Dietary Patterns Of The Aquatic Apex Predator, The African Tigerfish (Hydrocynus Vittatus). J Fish Biol Published Online July 27, 2023.

  15. Watanabe K, Kondo M, Ikenaka Y, Nakayama SMM, Ishizuka M. A Comparative Genomic And Phylogenetic Investigation Of The Xenobiotic Metabolism Enzymes Of Cytochrome P450 In Elephants Shows Loss In CYP2E And CYP4A. Animals (Basel) 13, 1939, 2023.

  16. Nakamura S, Yamazaki J, Matsumoto N, Inoue-Murayama M, Qi H, Yamanaka M, Nakanishi M, Yanagawa Y, Sashika M, Tsubota T, Ito H, Shimozuru M. Age estimation based on blood DNA methylation levels in brown bears. Mol Ecol Resour Published online August 1, 2023.

  17. Shijimaya T, Tahara T, Yamazaki J, Matsumoto Y, Nakamura N, Takahashi Y, Tomiyama T, Fukui T, Shibata T, Naganuma M. Comprehensive DNA methylation profiling of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients. Mol Carcinog Published online August 1, 2023.

  18. Shoda A, Murata M, Kimura M, Hara Y, Yonoichi S, Ishida Y, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N. Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin. J Vet Med Sci 23-0101, Published online August 4, 2023.

  19. Tahara T, Shijimaya T, Yamazaki J, Tomiyama T, Fukui T, Naganuma M. Telomere Shortening of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese Patients. Cancer Invest Published online 2023.

  20. Shijimaya T, Tahara T, Yamazaki J, Kobayashi S, Horitani A, Matsumoto Y, Nakamura N, Okazaki T, Takahashi Y, Tomiyama T, Honzawa Y, Fukata N, Fukui T, Naganuma M. Microarchitectures of Barrett’s esophagus associated with DNA methylation status. Epigenomics 15, 759-767, 2023.

  21. Tahara S, Tahara T, Yamazaki J, Shijimaya T, Horiguchi N, Funasaka K, Fukui T, Nakagawa Y, Shibata T, Naganuma M, Tsukamoto T, Ohmiya N. Helicobacter pylori infection associated DNA methylation in primary gastric cancer significantly correlates with specific molecular and clinicopathological features. Mol Carcinog Published online 2023.

  22. Khidkhan K, Yasuhira F, Saengtienchai A et al. Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors. Environ Pollut 122837, Published online November 4, 2023. 

  23. Ogasawara K, Yamada N, Nakayama SM, Watanabe Y, Saito K, Chiba A, Uchida Y, Ueda K, Takenaka Y, Kazama K, Kazama M, Yamagishi J, Mizukawa H, Ikenaka Y, Ishizuka M. Surveys of eleven species of wild and zoo birds and feeding experiments in white-tailed eagles reveal differences in the composition of the avian gut microbiome based on dietary habits between and within species. J Vet Med Sci Published online October 31, 2023.

​２０２２年

  1. Bataa B, Motohira K, Dugar D, Sainnokhoi T-A, Gendenpil L, Sainnokhoi T, Pelden B, Yohannes YB, Ganzorig S, Nakayama SMM, Ishizuka M, Ikenaka Y. Accumulation of Metals in the Environment and Grazing Livestock near A Mongolian Mining Area. Toxics 10, 2022.

  2. Furuta Y, Miura F, Ichise T, Nakayama SMM, Ikenaka Y, Zorigt T, Tsujinouchi M, Ishizuka M, Ito T, Higashi H. A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand. PLoS One 17, 2022.

  3. Hirai A, Sugio S, Nimako C, Nakayama SMM, Kato K, Takahashi K, Arizono K, Hirano T, Hoshi N, Fujioka K, Taira K, Ishizuka M, Wake H, Ikenaka Y. Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides. Sci Rep 12, 2022.

  4. Hirai A, Yamazaki R, Kobayashi A, Kimura T, Nomiyama K, Shimma S, Nakayama SMM, Ishizuka M, Ikenaka Y. Detection of Changes in Monoamine Neurotransmitters by the Neonicotinoid Pesticide Imidacloprid Using Mass Spectrometry. Toxics 10, 2022.

  5. Ishii C, Kawai YK, Ikenaka Y, Maekawa N, Ichii O, Nakayama SMM, Ishizuka M. Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens. Poult Sci 101, 2022.

  6. Kataba A, Botha TL, Nakayama SMM, Yohannes YB, Ikenaka Y, Wepener V, Ishizuka M. Environmentally relevant lead (Pb) water concentration induce toxicity in zebrafish (Danio rerio) larvae. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 252, 2022.

  7. Kondo M, Ikenaka Y, Nakayama SMM, Kawai YK, Ishizuka M. Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria). Animals (Basel) 12, 2022.

  8. Kondo M, Ikenaka Y, Nakayama SMM, Kawai YK, Ishizuka M. Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria). Animals (Basel) 12, 2022.

  9. Kondo M, Ikenaka Y, Nakayama SMM, Kawai YK, Mizukawa H, Mitani Y, Nomyama K, Tanabe S, Ishizuka M. Sulfotransferases (SULTs), enzymatic and genetic variation in Carnivora: Limited sulfation capacity in pinnipeds. Comp Biochem Physiol C Toxicol Pharmacol 263, 109476, 2023.

  10. Kubo S, Hirano T, Miyata Y, Ohno S, Onaru K, Ikenaka Y, Nakayama SMM, Ishizuka M, Mantani Y, Yokoyama T, Hoshi N. Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice. Toxicol Appl Pharmacol 456, 2022.

  11. Nagata N, Sawamura H, Morishita K, Hosoya K, Yokoyama N, Sasaoka K, Sasaki N, Nakamura K, Ikenaka Y, Takiguchi M. Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism. Journal of Veterinary Medical Science 84, 954-959, 2022.

  12. Nakata H, Eguchi A, Nakayama SMM, Yabe J, Muzandu K, Ikenaka Y, Mori C, Ishizuka M. Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study. Int J Environ Res Public Health 19, 2022.

  13. Nakata H, Nakayama SMM, Yabe J, Muzandu K, Kataba A, Ikeda-Araki A, Drisse MNB, Onyon LJ, Gorman J, Kritika P, Fukunaga H, Ikenaka Y, Kishi R, Ishizuka M. Narrative review of lead poisoning in humans caused by industrial activities and measures compatible with sustainable industrial activities in Republic of Zambia. Science of the Total Environment 850, 2022.

  14. de Necker L, Brendonck L, Gerber R, Lemmens P, Soto DX, Ikenaka Y, Ishizuka M, Wepener V, Smit NJ. Drought altered trophic dynamics of an important natural saline lake: A stable isotope approach. Science of the Total Environment 834, 2022.

  15. Nimako C, Ichise T, Hasegawa H, Akoto O, Boadi NO, Taira K, Fujioka K, Isoda N, Nakayama SMM, Ishizuka M, Ikenaka Y. Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population. Environ Int 162, 2022.

  16. Nishi M, Sugio S, Hirano T, Kato D, Wake H, Shoda A, Murata M, Ikenaka Y, Tabuchi Y, Mantani Y, Yokoyama T, Hoshi N. Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging. Journal of Veterinary Medical Science 84, 585-592, 2022.

  17. Nishizawa T, Ikenaka Y, Ichikawa G, Taguchi T. Thiamethoxam intoxication due to occupational inhalational exposure. BMJ Case Rep 15, 2022.

  18. Nomiyama K, Yamamoto Y, Eguchi A, Nishikawa H, Mizukawa H, Yokoyama N, Ichii O, Takiguchi M, Nakayama SMM, Ikenaka Y, Ishizuka M. Health impact assessment of pet cats caused by organohalogen contaminants by serum metabolomics and thyroid hormone analysis. Science of the Total Environment 842, 2022.

  19. Oo T, Sasaki N, Ikenaka Y, Ichise T, Nagata N, Yokoyama N, Sasaoka K, Morishita K, Nakamura K, Takiguchi M. Serum steroid profiling of hepatocellular carcinoma associated with hyperadrenocorticism in dogs: A preliminary study. Front Vet Sci 9, 1014792, 2022.

  20. Sasaki N, Ikenaka Y, Aoshima K, Aoyagi T, Kudo N, Nakamura K, Takiguchi M. Safety Assessment of Ultrasound-Assisted Intravesical Chemotherapy in Normal Dogs: A Pilot Study. Front Pharmacol 13, 837754, 2022.

  21. Sato H, Ishii C, Nakayama SMM, Ichise T, Saito K, Watanabe Y, Ogasawara K, Torimoto R, Kobayashi A, Kimura T, Nakamura Y, Yamagishi J, Ikenaka Y, Ishizuka M. Behavior and toxic effects of Pb in a waterfowl model with oral exposure to Pb shots: Investigating Pb exposure in wild birds. Environmental Pollution 308, 2022.

  22. Shimasaki M, Mizukawa H, Takaguchi K, Saengtienchai A, Ngamchirttakul A, Pencharee D, Khidkhan K, Ikenaka Y, Nakayama SMM, Ishizuka M, Nomiyama K. Contamination Status of Pet Cats in Thailand with Organohalogen Compounds (OHCs) and Their Hydroxylated and Methoxylated Derivatives and Estimation of Sources of Exposure to These Contaminants. Animals (Basel) 12, 2022.

  23. Shinya S, Kawai Y, Kondo M, Nakayama SMM, Ishizuka M, Ikenaka Y. Characteristics of cytochrome P450-dependent metabolism against acetamiprid in the musk shrew (Suncus murinus). Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 265, 2023.

  24. Shinya S, Sashika M, Minamikawa M, Itoh T, Yohannes YB, Nakayama SMM, Ishizuka M, Nimako C, Ikenaka Y. Estimation of the Effects of Neonicotinoid Insecticides on Wild Raccoon, Procyon lotor, in Hokkaido, Japan: Urinary Concentrations and Hepatic Metabolic Capability of Neonicotinoids. Environ Toxicol Chem 41, 1865-1874, 2022.

  25. Shinya S, Yohannes YB, Ikenaka Y, Nakayama SMM, Ishizuka M, Fujita S. Characteristics of cytochrome P450-dependent metabolism in the liver of the wild raccoon, Procyon lotor. Journal of Veterinary Medical Science 84, 1665-1672, 2022.

  26. Shoda A, Nishi M, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N. Quantitative elucidation of the transfer of the neonicotinoid pesticide clothianidin to the breast milk in mice. Toxicol Lett 373, 33-40, 2023.

  27. Suzuki T, Aoshima K, Yamazaki J, Kobayashi A, Kimura T. Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells. Vet Comp Oncol 20, 805-816, 2022.

  28. Takeda K, Manago K, Morita A, Kawai YK, Yasuo N, Sekijima M, Ikenaka Y, Hashimoto T, Minato R, Oyamada Y, Horikoshi K, Suzuki H, Ishizuka M, Nakayama SMM. Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon). Ecotoxicol Environ Saf 243, 2022.

  29. Uno Y, Murayama N, Ijiri M, Kawaguchi H, Yamato O, Shiraishi M, Asano A, Teraoka H, Mizukawa H, Nakayama SMM, Ikenaka Y, Ishizuka M, Yamazaki H. Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 50, 1434-1441, 2022.

  30. Yohannes YB, Nakayama SMM, Yabe J, Toyomaki H, Kataba A, Nakata H, Muzandu K, Ikenaka Y, Choongo K, Ishizuka M. Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia. Environ Sci Pollut Res Int 29, 6622-6632, 2022.

  31. Yohannes YB, Nakayama SMM, Yabe J, Toyomaki H, Kataba A, Nakata H, Muzandu K, Miyashita C, Ikenaka Y, Choongo K, Ishizuka M. Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb). Epigenetics 17, 2377-2388, 2022.

  32. Yuan TH, Yu MT, Ikenaka Y, Chen YH, Nakayama SF, Chan CC. Characteristics of neonicotinoid and metabolite residues in Taiwanese tea leaves. J Sci Food Agric 102, 341-349, 2022.

​２０２１年

  1. Gerber R, Bouwman H, Govender D, Ishizuka M, Ikenaka Y, Yohannes YB, Smit NJ, Wepener V. Levels of DDTs and other organochlorine pesticides in healthy wild Nile crocodiles (Crocodylus niloticus) from a flagship conservation area. Chemosphere 264, 2021.

  2. Hirano T, Miyata Y, Kubo S et al. Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid pesticide clothianidin in male mice. Toxicol Lett 342, 95-103, 2021.

  3. Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y. Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition. Toxicol Appl Pharmacol 430, 2021.

  4. Kataba A, Botha TL, Nakayama SMM, Yohannes YB, Ikenaka Y, Wepener V, Ishizuka M. Environmentally relevant lead (Pb) water concentration induce toxicity in zebrafish (Danio rerio) larvae. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 252, 2022.

  5. Kataba A, Nakayama SMM, Nakata H, Toyomaki H, Yohannes YB, Yabe J, Muzandu K, Zyambo G, Kubota A, Matsukawa T, Yokoyama K, Ikenaka Y, Ishizuka M. An investigation of the wild rat crown incisor as an indicator of lead (Pb) exposure using inductively couple plasma mass spectrometry (ICP-MS) and laser ablation ICP-MS. Int J Environ Res Public Health 18, 1-15, 2021.

  6. Kataba A, Nakayama SMM, Yohannes YB, Toyomaki H, Nakata H, Ikenaka Y, Ishizuka M. Effects of zinc on tissue uptake and toxicity of lead in sprague dawley rat. Journal of Veterinary Medical Science 83, 1674-1685, 2021.

  7. Khidkhan K, Ikenaka Y, Ichise T, Nakayama SMM, Mizukawa H, Nomiyama K, Iwata H, Arizono K, Takahashi K, Kato K, Ishizuka M. Interspecies differences in cytochrome P450-mediated metabolism of neonicotinoids among cats, dogs, rats, and humans. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 239, 2021.

  8. Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N. Effects of in utero and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid clothianidin on the reproductive organs of female mice. Journal of Veterinary Medical Science 83, 746-753, 2021.

  9. Maeda M, Kitauchi S, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Tabuchi Y, Yokoyama T, Hoshi N. Fetal and lactational exposure to the no-observed-adverse-effect level (Noael) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice. Journal of Veterinary Medical Science 83, 542-548, 2021.

  10. Nakata H, Nakayama SMM, Yabe J, Muzandu K, Toyomaki H, Yohannes YB, Kataba A, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M. Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia. Chemosphere 262, 2021.

  11. Nakata H, Nakayama SMM, Yabe J, Muzandu K, Toyomaki H, Yohannes YB, Kataba A, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M. Assessment of LeadCare® II analysis for testing of a wide range of blood lead levels in comparison with ICP–MS analysis. Chemosphere 271, 2021.

  12. Nimako C, Hirai A, Ichise T, Akoto O, Nakayama SMM, Taira K, Fujioka K, Ishizuka M, Ikenaka Y. Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods. Toxicol Rep 8, 1657-1664, 2021.

  13. Nimako C, Ikenaka Y, Akoto O, Bortey-Sam N, Ichise T, Nakayama SMM, Asante KA, Fujioka K, Taira K, Ishizuka M. Human Exposures to Neonicotinoids in Kumasi, Ghana. Environ Toxicol Chem 40, 2306-2318, 2021.

  14. Nimako C, Ikenaka Y, Akoto O, Fujioka K, Taira K, Arizono K, Kato K, Takahashi K, Nakayama SMM, Ichise T, Ishizuka M. Simultaneous quantification of imidacloprid and its metabolites in tissues of mice upon chronic low-dose administration of imidacloprid. J Chromatogr A 1652, 2021.

  15. Nimako C, Ikenaka Y, Okamatsu-Ogura Y, Bariuan J V., Kobayashi A, Yamazaki R, Taira K, Hoshi N, Hirano T, Nakayama SMM, Ishizuka M. Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in c57bl/6j male mice. Journal of Veterinary Medical Science 83, 487-500, 2021.

  16. Sajiki Y, Konnai S, Ikenaka Y, Gulay KCM, Kobayashi A, Parizi LF, João BC, Watari K, Fujisawa S, Okagawa T, Maekawa N, Logullo C, da Silva Vaz I, Murata S, Ohashi K. Tick saliva-induced programmed death-1 and PD-ligand 1 and its related host immunosuppression. Sci Rep 11, 2021.

  17. Sasaki N, Ikenaka Y, Inoue Y, Ichise T, Nagata N, Ishizuka M, Nakayama SMM, Nakamura K, Takiguchi M. Urinary free metanephrines measurement in dogs with adrenal gland diseases using a new simple liquid chromatography tandem mass spectrometry method. Journal of Veterinary Medical Science 83, 648-655, 2021.

  18. Sasaki N, Oo T, Yasuda Y, Ichise T, Nagata N, Yokoyama N, Sasaoka K, Morishita K, Nakayama SM, Ishizuka M, Nakamura K, Takiguchi M, Ikenaka Y. Simultaneous steroids measurement in dogs with hyperadrenocorticism using a column-switching liquid chromatography-tandem mass spectrometry method. Journal of Veterinary Medical Science 83, 1634-1642, 2021.

  19. Shoji A, Elliott KH, Watanuki Y, Basu N, Whelan S, Cunningham J, Hatch S, Mizukawa H, Nakayama SMM, Ikenaka Y, Ishizuka M, Aris-Brosou S. Geolocators link marine mercury with levels in wild seabirds throughout their annual cycle: Consequences for trans-ecosystem biotransport. Environmental Pollution 284, 2021.

  20. Suzuki T, Hirai A, Khidkhan K, Nimako C, Ichise T, Takeda K, Mizukawa H, Nakayama SMM, Nomiyama K, Hoshi N, Maeda M, Hirano T, Sasaoka K, Sasaki N, Takiguchi M, Ishizuka M, Ikenaka Y. The effects of fipronil on emotional and cognitive behaviors in mammals. Pestic Biochem Physiol 175, 2021.

  21. Taira K, Kawakami T, Weragoda SK, Herath HMAS, Ikenaka Y, Fujioka K, Hemachandra M, Pallewatta N, Aoyama Y, Ishizuka M, Bonmatin JM, Komori M. Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka. Sci Rep 11, 2021.

  22. Takeda K, Ikenaka Y, Fourches D, Tanaka KD, Nakayama SMM, Triki D, Li X, Igarashi M, Tanikawa T, Ishizuka M. The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus). Pestic Biochem Physiol 173, 2021.

  23. Torimoto R, Ishii C, Sato H, Saito K, Watanabe Y, Ogasawara K, Kubota A, Matsukawa T, Yokoyama K, Kobayashi A, Kimura T, Nakayama SMM, Ikenaka Y, Ishizuka M. Analysis of lead distribution in avian organs by LA-ICP-MS: Study of experimentally lead-exposed ducks and kites. Environmental Pollution 283, 2021.

  24. Toyomaki H, Yabe J, Nakayama SMM, Yohannes YB, Muzandu K, Mufune T, Nakata H, Ikenaka Y, Kuritani T, Nakagawa M, Choongo K, Ishizuka M. Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia. Environmental Pollution 286, 2021.

  25. Wolmarans NJ, Bervoets L, Gerber R, Yohannes YB, Nakayama SM, Ikenaka Y, Ishizuka M, Meire P, Smit NJ, Wepener V. Bioaccumulation of DDT and other organochlorine pesticides in amphibians from two conservation areas within malaria risk regions of South Africa. Chemosphere 274, 2021.

  26. Yamamura Y, Takeda K, Kawai YK, Ikenaka Y, Kitayama C, Kondo S, Kezuka C, Taniguchi M, Ishizuka M, Nakayama SMM. Sensitivity of turtles to anticoagulant rodenticides: Risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species. Aquatic Toxicology 233, 2021.

  27. Yamazaki J, Jelinek J, Yokoyama S, Takiguchi M. Genome-wide DNA methylation profile in feline haematological tumours: A preliminary study. Res Vet Sci 140, 221-228, 2021.

  28. Yamazaki J, Matsumoto Y, Jelinek J, Ishizaki T, Maeda S, Watanabe K, Ishihara G, Yamagishi J, Takiguchi M. DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing. Sci Rep 11, 2021.

  29. Yamazaki J, Meagawa S, Jelinek J, Yokoyama S, Nagata N, Yuki M, Takiguchi M. Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs. Res Vet Sci 139, 193-199, 2021.

  30. Yamazaki J, Toyomaki H, Nakayama SMM, Yabe J, Muzandu K, Jelinek J, Yokoyama S, Ikenaka Y, Takiguchi M, Ishizuka M. Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia. Environmental Pollution 286, 2021.

  31. Yamazaki J, Toyomaki H, Nakayama SMM, Yabe J, Muzandu K, Jelinek J, Yokoyama S, Ikenaka Y, Takiguchi M, Ishizuka M. Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia. Environmental Pollution 286, 2021.

​２０２０年

  1. Doya R, Nakayama SMM, Nakata H, Toyomaki H, Yabe J, Muzandu K, Yohannes YB, Kataba A, Zyambo G, Ogawa T, Uchida Y, Ikenaka Y, Ishizuka M. Land Use in Habitats Affects Metal Concentrations in Wild Lizards around a Former Lead Mining Site. Environ Sci Technol 54, 14474-14481, 2020.

  2. Erasmus A, Ikenaka Y, Nakayama SMM, Ishizuka M, Smit NJ, Wepener V. Trophic transfer of pollutants within two intertidal rocky shore ecosystems in different biogeographic regions of South Africa. Mar Pollut Bull 157, 2020.

  3. Gerber R, Bouwman H, Govender D, Ishizuka M, Ikenaka Y, Yohannes YB, Smit NJ, Wepener V. Levels of DDTs and other organochlorine pesticides in healthy wild Nile crocodiles (Crocodylus niloticus) from a flagship conservation area. Chemosphere 264, 2021.

  4. Ishii C, Ikenaka Y, Nakayama SMM, Kuritani T, Nakagawa M, Saito K, Watanabe Y, Ogasawara K, Onuma M, Haga A, Ishizuka M. Current situation regarding lead exposure in birds in Japan (2015–2018); lead exposure is still occurring. Journal of Veterinary Medical Science 82, 1118-1123, 2020.

  5. Ishizaki T, Yamazaki J, Meagawa S, Yokoyama N, Aoshima K, Takiguchi M, Kimura T. Long interspersed nucleotide element-1 hypomethylation in canine malignant mucosal melanoma. Vet Comp Oncol 18, 854-860, 2020.

  6. Kataba A, Botha TL, Nakayama SMM, Yohannes YB, Ikenaka Y, Wepener V, Ishizuka M. Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio). Aquatic Toxicology 227, 2020.

  7. Khidkhan K, Ikenaka Y, Ichise T, Nakayama SMM, Mizukawa H, Nomiyama K, Iwata H, Arizono K, Takahashi K, Kato K, Ishizuka M. Interspecies differences in cytochrome P450-mediated metabolism of neonicotinoids among cats, dogs, rats, and humans. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 239, 2021.

  8. Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Takiguchi M, Tanabe S, Ishizuka M. Altered hepatic cytochrome p450 expression in cats after chronic exposure to decabromodiphenyl ether (Bde-209). Journal of Veterinary Medical Science 82, 978-982, 2020.

  9. Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. Journal of Biological Chemistry 295, 8048-8063, 2020.

  10. Nakata H, Nakayama SMM, Yabe J, Muzandu K, Toyomaki H, Yohannes YB, Kataba A, Zyambo G, Ikenaka Y, Choongo K, Ishizuka M. Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia. Chemosphere 262, 2021.

  11. Nakayama SMM, Morita A, Ikenaka Y, Kawai YK, Watanabe KP, Ishii C, Mizukawa H, Yohannes YB, Saito K, Watanabe Y, Ito M, Ohsawa N, Ishizuka M. Avian interspecific differences in VKOR activity and inhibition: Insights from amino acid sequence and mRNA expression ratio of VKORC1 and VKORC1L1. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 228, 2020.

  12. Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM, Ishizuka M, Hoshi N. Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice. Toxicol Lett 322, 32-38, 2020.

  13. Ohta H, Yamazaki J, Jelinek J, Ishizaki T, Kagawa Y, Yokoyama N, Nagata N, Sasaki N, Takiguchi M. Genome-wide DNA methylation analysis in canine gastrointestinal lymphoma. Journal of Veterinary Medical Science 82, 632-638, 2020.

  14. Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. Journal of Veterinary Medical Science 82, 350-359, 2020.

  15. Takeda K, Morita A, Ikenaka Y, Nakayama SMM, Ishizuka M. Comparison of two reducing agents dithiothreitol and tris(3-hydroxypropyl)phosphine for in vitro kinetic assay of vitamin K epoxide reductase. Vet Anim Sci 9, 100095, 2020.

  16. Tanaka K, Takada H, Ikenaka Y, Nakayama SMM, Ishizuka M. Occurrence and concentrations of chemical additives in plastic fragments on a beach on the island of Kauai, Hawaii. Mar Pollut Bull 150, 2020.

  17. Tanaka K, Watanuki Y, Takada H, Ishizuka M, Yamashita R, Kazama M, Hiki N, Kashiwada F, Mizukawa K, Mizukawa H, Hyrenbach D, Hester M, Ikenaka Y, Nakayama SMM. In Vivo Accumulation of Plastic-Derived Chemicals into Seabird Tissues. Current Biology 30, 723-728.e3, 2020.

  18. Togao M, Nakayama SMM, Ikenaka Y, Mizukawa H, Makino Y, Kubota A, Matsukawa T, Yokoyama K, Hirata T, Ishizuka M. Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry. Chemosphere 238, 2020.

  19. Toyomaki H, Yabe J, Nakayama SMM, Yohannes YB, Muzandu K, Liazambi A, Ikenaka Y, Kuritani T, Nakagawa M, Ishizuka M. Factors associated with lead (Pb) exposure on dogs around a Pb mining area, Kabwe, Zambia. Chemosphere 247, 2020.

  20. Wyckhuys KAG, Aebi A, Bijleveld van Lexmond MFIJ, Bojaca CR, Bonmatin JM, Furlan L, Guerrero JA, Mai T V., Pham H V., Sanchez-Bayo F, Ikenaka Y. Resolving the twin human and environmental health hazards of a plant-based diet. Environ Int 144, 2020.

  21. Yabe J, Nakayama SM, Nakata H, Toyomaki H, Yohannes YB, Muzandu K, Kataba A, Zyambo G, Hiwatari M, Narita D, Yamada D, Hangoma P, Munyinda NS, Mufune T, Ikenaka Y, Choongo K, Ishizuka M. Current trends of blood lead levels, distribution patterns and exposure variations among household members in Kabwe, Zambia. Chemosphere 243, 2020.

  22. Yohannes YB, Nakayama SM, Yabe J, Nakata H, Toyomaki H, Kataba A, Muzandu K, Ikenaka Y, Choongo K, Ishizuka M. Blood lead levels and aberrant DNA methylation of the ALAD and p16 gene promoters in children exposed to environmental-lead. Environ Res 188, 2020.

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